모자보건과 기능영양(2023년 4권1호)-(1) 문헌 분석을 통한 소아청소년 세신 처방의 안전성 고찰 – Aristolochic Acid를 중심으로 -.pdf

Kim Byung Chan1, Kim Tae Hwan2,* 

1 Kyung Hee University Korean Medicine Hospital

2 Department of Pediatrics, Kyung Hee University Korean Medicine Hospital
 

Objectives: This study was conducted to review safety of herbal medicine for pediatrics, 

especially Asarum sieboldii, Asarum heterotropoides, and to design herbal medicine safety 

assessment model.

Methods: Literature search was done to study safety of herbal medicine for pediatrics, 

especially Asarum sieboldii, Asarum heterotropoides. UptoDate, Pubmed, Google Scholarship, 

DBPIA were used in the research. Search words were ‘pediatrics AND herbal medicine’, 

‘Safety of Herbal treatment’, ‘Asarum sieboldii’, ‘Asarum heterotropoides’, etc.

Results: 5 steps of herbal medicine safety assessment model were planned and done. Those 

include chemical structure analysis, pathologic analysis, pharmokinetics analysis, dosage – toxicology 

analysis, bibliographic analysis. Through the 5 assessment steps, we estimated that aristolochic 

acid nephropathy’s risk factor can be infants below 36 months, renal failure. We also estimated 

the safety standard for the herbal medicine and the calculation were same by dosage-toxicology 

and bibliographic analysis. We also found out that while reading medical book from past, the 

doctor should pay attention to drug taking methods.

Conclusions: 5 steps of herbal medicine safety assessment model should be introduced to 

other herbal medicines for fast assessment by the doctors before prescripting to pediatrics. 

However, backup experimental data, safety clinical trials for pediatrics should be more held for 

further evidence.

Key Words: Safety, Herbal Medicine, Pediatrics, Aristolochic acid, Asarum Sieboldii, Asarum 

Heterotropoides