모자보건과 기능영양(2023년 4권1호)-(3) 문헌 분석을 통한 소아청소년 감초 처방의 안전성 고찰 – Glycyrrhizin을 중심으로.pdf

Kim Byung Chan1,*⋅Seo Hae Sun2 

1 Kyung Hee University Korean Medicine Hospital

2 Department of Pediatrics, Kyung Hee University Korean Medicine Hospital

Objectives: This study was conducted to review safety of herbal medicine for pediatrics, 

especially Glycyrrhiza uralensis, and to design herbal medicine safety assessment model.

Methods: Literature search was done to study safety of herbal medicine for pediatrics, 

especially Glycyrrhiza uralensis. UptoDate, Pubmed, Google Scholarship, DBPIA were used in 

the research. Search words were ‘pediatrics AND herbal medicine’, ‘Safety of Herbal medicine’, 

‘Glycyrrhiza uralensis’, etc.

Results: 5 steps of herbal medicine safety assessment model were planned and done. Those 

include chemical structure analysis, pathologic analysis, pharmokinetics analysis, dosage - 

toxicology analysis, bibliographic analysis. Through the 5 assessment steps, we estimated that 

pseudo - aldosteronism’s risk factor can be infants below 12 months, constipation, low albumin 

levels. We also estimated the safety standard for the herbal medicine and the calculation were 

same by dosage - toxicology and bibliographic analysis. We also found out that while reading 

medical book from past, the doctor should pay attention to drug taking methods.

Conclusions: 5 steps of herbal medicine safety assessment model should be introduced to 

other herbal medicines for fast assessment by the doctors before prescripting to pediatrics. 

However, backup experimental data, safety clinical trials for pediatrics should be more held for 

further evidence.

Key Words: Safety, Herbal Medicine, Pediatrics, Glycyrrhizin, Glycyrrhiza uralensis